Shilpi Saha et al from Bose Institute recently published a paper in BMC Complement Altern Med titled “Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuit“. This papers aimed at exploring the underlying mechanism of anti-cancer effect of homeopathic medicine Calcarea carb by studying the molecular mechanism.
The team investigated the role of calcarea carbonica on tumour regression and apoptosis (cancer cell death) in mice having Ehrlich’s ascites carcinoma (EAC) and Sarcoma-180 (S-180). Modern techniques like Trypan blue dye-exclusion test, flow cytometric, Western blot and reverse transcriptase-PCR techniques were used to study this effect. Also the team studied the role of p53 pathway in calcarea carbonica-induced apoptosis in cancer cells.
The team observed that calcarea carbonica administration resulted in 30-35% tumor cell apoptosis. It has been put forward that a “two-step” mechanism is involved for Calcarea carbonica to induce apoptosis in cancer cells and that is (1) activation of the immune system of the host; and (2) induction of cancer cell apoptosis via immuno-modulatory circuit in p53-dependent manner .
The study serves an important study since it proposes the long awaited answers to many question in homeopathic cure for e.g. mode of action. The significant observation of involvement of immuno-modulatory circuit in Calcarea carb action may open new vistas for future research in cancer.
The paper is freely available at link: http://www.ncbi.nlm.nih.gov/pubmed/24053127
*The views here are expressed by Dr. Saurav Arora under Initiative to Promote Research in Homeopathy. For more homeopathic research updates visit www.audesapere.in
A good addition in knowledge.